Faculty

Department of Ion Signaling and Response,The Sakaguchi Laboratory

Biochemistry, Vascular physiology

After uncovering bicarbonate-sensing G protein receptor, GPR30, I demonstrated that GPR30 deficiency controlled blood flow, being involved in ischemia-reperfusion injury. Our research reach is now extending to drug discovery.

Department of Multidimensional Analysis of Gastrointestinal Biology,The Sakaguchi Laboratory

Department of Multidimensional Analysis of Gastrointestinal Biology, School of Medicine, The Sakaguchi Laboratory, Keio University School of Medicine

We aim to elucidate the pathogenesis of human gastrointestinal diseases using single-cell RNA-seq and spatial transcriptomics analysis as well as localization and kinetic analysis of immune cells at the single-cell level in the field of gastrointestinal immunology and endoscopy.

The Ishii-Ishibashi Laboratory - Department of Extended Intelligence for Medicine

Data-driven biomedical science

To develop precise prediction-based treatments and preventions, we are studying diverse and dynamic processes of patients from their data. For that, new analytical methods by combining a causal model, information geometry, machine learning and a reduced order model for non-linear phenomenon are developing. The knowledge gained from these novel analyses will be implemented in medicine by the concept of extended intelligence.

The Ishii-Ishibashi Laboratory - Department of Extended Intelligence for Medicine

Data science, Mathematical medical science, Cognitive neuroscience

Gaining insights from health and clinical data analysis that lead to personalized/preventive medicine through knowledge discovery by visualization, interdisciplinary approaches that utilize mathematical modeling and machine learning, and construction of hybrid intelligence in which experts and machines collaborate.

Division of Brain Sciences, Institute for Advanced Medical Research

Brain sciences, Neurochemistry, Biological psychiatry

The aim of the Division of Brain Sciences is a multi-layered (gene, cell, circuit) understanding of brain functions. We regard the brain as the sum of its parts—neuron, glia, and vasculature—and explores the unseen interaction between the brain and peripheral organs that engages in higher brain functions such as emotion and motivation. These efforts will lead to the development of novel treatments for mental illness.

Division of Tumor Immunology, Institute for Advanced Medical Research

Development of immunotherapy for cancer and chronic inflammation

We aim to develop a novel immunotherapeutic approach for cancer and chronic inflammation through elucidating the role of immune system in these diseases. We are especially interested in adoptive immunotherapy, in which immune cells are used as a “living drug” to attack cancer cells.

Pulmonary Medicine

Respiratory medicineInflammatory lung disease (asthma, COPD), Sleep apnea syndrome

Research on the pathophysiology and development of novel treatments of inflammatory lung diseases, especially severe asthma and also screening methods for patients with sleep apnea syndrome and methods for evaluating therapeutic effects.

Pulmonary Medicine

Pulmonary Medicine, Cancer Biology

My research goals are to understand the causes of lung diseases including lung cancer and to obtain novel findings which can contribute to the development of effective treatments.

Cardiology

Cardiology, Regenerative medicine

Elucidation of the pathogenesis of heart disease and development of new therapies with regenerative approach.

Cardiology

Cardiology, Cardiovascular Disease, Quality and Outcomes Research

Dr Kohsaka is engaged in outcome research in the field of cardiology through multicenter registry studies, accumulation of clinical administrative data, and international clinical trials. The foundation of his work is to "respond to the practical clinical questions", focusing on optimizing clinical pathways, updating recommendations in clinical practice guidelines, and improving various biases through research findings.

Cardiology

Cardiac catheterization

We are conducting studies on minimally invasive transcatheter treatments for structural heart diseases, (TAVI, MTEER, tricuspid valve treatment, and transcatheter LAAC) through multi-center registries or randomized controlled trials.

Gastroenterology and Hepatology

Basic and clinical research of gastrointestinal immunity disorders

Clinical development of new drugs and treatments for IBD as well as liver and pancreatic immunity disorders. Developing preventive medicine that seeks to unify immunology, genetics, and nutritional science.

Gastroenterology and Hepatology

Gastroenterology and Hepatology

We are trying to elucidate the pathogenesis and underlying mechanism of various liver diseases including acute liver injury, chronic liver injury, liver cirrhosis, and hepatocellular carcinoma from the multiple view on immunology, metabolism, and microorganism, leading to a development of new diagnosis and medical treatment.

Gastroenterology and Hepatology

Gastroenterology, inflammatory bowel disease, and systems medicine.

Our research goal is to elucidate the diverse molecular and cellular networks involved in inflammation, tissue repair and fibrosis processes in digestive organs at the cellular, tissue and organ level. Utilizing biological methods and multi-omics techniques, we aim to decipher these complex networks and develop novel therapeutic strategies for inflammatory diseases of digestive organs.

Neurology

Neurological therapeutics

We aim to develop actual therapeutics by every conceivable means – from advancement of translational research to home care medicine – to improve the quality of life of patients suffering from various neurological diseases.

Neurology

Parkinson's disease and related disorders

Clinical research based on a database that contains clinical information on a large number of Parkinson's disease patients.Establishment of novel neuroimaging biomarkers for Parkinson's disease and related disorders using advanced MRI technology.

Hematology

Hematology, Molecular oncology, Cancer genetics

Genetic dissection of molecular pathogenesis in human malignancies, particularly in hematologic neoplasms; Establishing clinical relevance of genetic alterations (as therapeutic targets and/or biomarkers); Implementation of precision medicine through clinical sequencing.

Hematology

Hematology

We aim to improve the outcomes of hematopoietic stem cell transplantation and CAR-T cell therapy for refractory hematologic diseases through ex vivo expansion technologies of hematopoietic stem cells and nationwide database analyses.

Rheumatology

Rheumatoid arthritis, Connective tissue diseases

Clinical application of inhibiting inflammatory cytokines to treat patients with rheumatoid arthritis and connective tissue diseases and clarification of the mechanism　of their efficacy in relation to the pathogenesis of the diseases.

Nephrology, Endocrinology and Metabolism

Nephrology, Hypertension

Our research aims to obtain a deep understanding of the pathophysiology of age-related diseases, including chronic kidney disease, hypertension, and metabolic disorders such as diabetes, which have been on the rise in recent aging society, and to contribute to establish new therapeutic strategies.

Nephrology, Endocrinology and Metabolism

Endocrinology, Metabolism, Nephrology, Chronobiology

Using a systems biology approach, research projects aim to provide a holistic understanding of the mechanisms by which the eating behavior, sleep, biological clock, and environment impinge on the temporal profiles of hormones, humoral and neural factors and entrain the cellular and tissue level oscillation, and to define the discernible signature of the pre-symptomatic state.

General and Gastroenterological Surgery

Gasteroenterology; surgical oncology; endoscopic surgery; multidisciplinary solid tumor therapy; surgical infections; bodily reactions to invasive surgery; sentinel node navigation surgery

Research utilizing an approach based on the sentinel node theory. Analyzing the mechanisms of metastasis of lymph node cancers and their regulation. Applying microscopic metastasis and capillary blood cancer cell detection methods to realize individualized, multidisciplinary treatment mehthods for digestive organ cancers. Research into reactions to invasive surgery, and surgery-related infections.

General and Gastroenterological Surgery

HPB and Liver transplant surgery specialist

Dr. Yuta Abe specializes in advanced hepatobiliary and pancreatic (HBP) surgery, with a particular focus on complex procedures for HBP malignancies and the development and implementation of minimally invasive techniques. His clinical research aims to improve treatment outcomes for perihilar cholangiocarcinoma through multidisciplinary approaches. He is also actively involved in standardizing and promoting robotic liver resection as a safe and effective surgical option worldwide.

General and Gastroenterological Surgery

Vascular Surgery, Liver transplant surgery

Evaluation of vascular morphological changes of bioresorbable vascular scaffolds in clinical study and assessment of morphological findings. Development of a new treatment strategy for acute limb ischemia using hydrogen gas. Visualization of peripheral vessels by photoacoustic imaging.

General and Gastroenterological Surgery

Gastroenterological surgery (esophagus and stomach); surgical oncology; endoscopic treatment, endoscopic surgery; solid tumor multidisciplinary therapies; surgical infections, bodily reactions to invasive surgery; individually minimized minor surgery using sentinel lymph node theory

Research utilizing an approach based on the sentinel node theory. Analyzing the mechanisms of metastasis of lymph node cancers and their regulation. Minimally invasive treatment for early upper GI cancer. Multidisciplinary treatment method for advanced upper GI cancer Research into reactions to invasive surgery, and surgery-related infections.