Faculty

Dermatology

Autoimmunity, Allergies, Skin Barrier, Skin Immunity

Elucidating pathophysiological and immunological mechanisms in tissue-specific autoimmune disorders, and clarifying fundamental mechanisms of peripheral tolerance by analyzing the skin as an immune organ. Clarifying the mechanisms of allergy diseases at the molecular level from the point of view of skin barrier dysfunction, and developing novel therapeutic and preventive strategies. Elucidating the pathophysiological mechanisms of severe forms of drug eruption.

Dermatology

Skin immunology, autoimmune diseases, T cell biology

Elucidating pathophysiology of immune-related skin diseases, especially autoimmune blistering diseases and drug adverse reactions, via mainly understanding roles of T cells in the diseases and proposing new therapeutic approaches.

Dermatology

Dermatologic Oncology

Translational research to develop new treatments for skin cancers such as extramammary Paget's disease, malignant melanoma, and squamous cell carcinoma.

Urology

Understanding the Oncogenesis of Urological Cancers and Developing Novel Cancer Therapies

Aiming for an integrative understanding of the development of cancer from precancerous lesions and the mechanisms of metastasis; developing innovative new treatments with a focus on the cellular-biological features in cytokine production and neoangiogenesis, etc.

Urology

Pediatric urology and kidney transplantation

1)Analysis of mesenchymal stem cell therapy and its mechanism for renal fibrosis induced by obstructive uropathy; 2)Development of the noninvasive diagnostic method for vesicoureteral reflux, the most important underlying disease of urinary tract infection, using color Doppler ultrasonography

Urology

Metastatic Renal Cell Carcinoma

1) Exploration of predictive biomarkers for metastatic renal cell carcinoma.; 2) Elucidation of drug resistance mechanisms in metastatic renal cell carcinoma.

Otorhinolaryngology, Head and Neck Surgery

Otolaryngology, Head and Neck Surgery; Skull base surgery; Head and Neck Oncology; Minimally invasive head and neck surgery

Development of minimally invasive treatments for head and neck tumors. Developing new treatments targeting recurrent and metastatic head and neck cancer. Research concerning the pathophysiology of rare tumors in head and neck tumors, such as carotid body tumors.

Otorhinolaryngology, Head and Neck Surgery

Lateral skull base surgery, Otology, Audiology, Vestibular Schwannoma

I specialize in the surgical treatment of intractable diseases of the lateral skull base, and promote multifaceted clinical research to improve the prognosis of vestibular schwannoma in particular. In addition, I work on research and social implementation for early detection and intervention of hearing loss.

Neuropsychiatry

Neuropsychology and Geriatric Psychiatry

Elucidating and developing treatments and rehabilitation techniques targeted at higher-level brain function disorders and cognitive impairments caused by brain damage. Analyzing cognitive impairments of psychoneural disorders related to depression using functional neuroimaging.

Neuropsychiatry

Neuropsychology, Forensic Psychiatry

Investigating brain function disorders and their connection with society through higher level brain function disorders, brain imaging, and psychiatric examinations.

Neuropsychiatry

Neuropsychopharmacology, Brain imaging

Optimization of the current pharmacotherapy and the development of new treatments for psychiatric disorders. Elucidating the pathophysiology of psychiatric disorders based on brain imaging using positron emission tomography (PET) and magnetic resonance imaging (MRI).

Diagnostic Radiology

Diagnostic Radiology

"1.Constructing optimum image diagnostic algorithms in the field ofcardiology and urology.2.Aiming for further human-body visualization by developing new devicesor techniques (microcirculatory system, lymphatic system, and peripheralnervous system).3.Assessing clinical application of four-dimensional dynamic imaging.

Diagnostic Radiology

Body MRI

My research interests focus on the clinical implementation of perfusion, diffusion and dynamic magnetic resonance imaging (MRI). The fast imaging techniques are hot topics in this field and we investigated the ultra-fast imaging in body MRI. We are also dedicated to improving and updating the myocardial T1 mapping and 4D flow in cardiovascular MRI.

Diagnostic Radiology

Diagnostic Radiology

Research and development of tissue-specific contrast media as well as imaging diagnostics of the abdomen and urinary organs using MRIs. Developing systems of non-invasive external diagnosis of cancers using MRIs (particularly of liver, pancreas, and prostate cancers) at the microscopic level. Also researching in vivo tissue diagnostic techniques using various tissue-specific contrast agents.

Radiation Oncology

Radiation Oncology, Radiation Therapy, Radiation Biology

Radiation oncology; radiation biologyIn clinical research, performing adaptive magnification of stereotactic radiation therapy, intensity modulated radiotherapy, image-guided radiotherapy, as well as radiation within tissue and cavities in various types of cancer treatments. Also evaluating the effectiveness of chemotherapy combined with radiation therapy.In basic research, examining chromosome and genetic mutation as a result of radiation exposure; and molecular biological investigation to predict the efficacy of radiation therapy.

Radiation Oncology

Radiation Oncology

Developing new methods of high-precision radiation therapies beginning with intensity-modulated radiation therapy and stereotactic radiosurgery. Investigation of expanding the applications of combined therapies using brachytherapy and external irradiation, and researching dose optimization.

Anesthesiology

Sepsis and Myocardial Function, Gastrointestinal Defense Mechanisms, Volatile Anesthetics and Microcirculatory Disorders, Epidural Anesthesia and Immune System

Clarifying the underlying mechanisms of host defense system against invasive stress. We are currently engaged in both basic and clinical research regarding protective approaches for myocardial dysfunction during sepsis and gut barrier function in the critically ill, and modulation of the immune system by epidural and/or inhalational anesthesia.

Anesthesiology

Multidisciplinary pain management for chronic pain

Establishment of multidisciplinary treatment for regractory chronic pain.　Development of useful biomarkers for objective assessment of chronic pain.

Emergency and Critical Care Medicine

Acute medicine, traumatology, burn care, surgical infections, infection prevention and control, biological reactions and pharmacokinetics under invasive stress

Analysis of biological reactions under invasive stress conditions using two-hit animal models (endotoxin administration after burn priming, etc.) and analysis of pharmacokinetics as it relates to antimicrobial and antifungal drugs in critically ill patients. Regenerative medicine in critical care (such as the application of cell technology for burn treatment).

Dentistry and Oral Surgery

Periodontology

1) Research on periodonotopathic bacteria; <br>2) Resarch on oral tissue regeneration using mesenchymal stem cells and iPS cells; <br>3) Analysis of the sensitivity of antimicrobial agents against periodontopathic bacteria; <br>4) Clinical research on sonic toothbrush cleaning.

Dentistry and Oral Surgery

Oral medicine, autoimmune disease, care of oral fuction

Research of the pathophysiological mechanism of oral symptoms and develop the treatment strategies of refractory oral mucosal diseases by basic and clinical research. Maintain and manage the oral function of perioperative patients by collaboration with the medical department.

Laboratory Medicine

Laboratory Medicine, Laboratory Hematology

Establishment of laboratory methods using new experimental technologiesStudies for the diagnosis of hematologic disorders (Relationship between genetic abnormalities and morphology of blood cells, Objective evaluation of blood cell morphology, Detection of minimal residual diseases using flow cytometric analysis, etc)

Laboratory Medicine

Laboratory Medicine

I am working with various research interests focusing on tumor biology, laboratory hematology, clinical immunology, genetic testing, and analytical chemistry (especially mass spectrometry). I am also interested in promoting contribution of laboratory medicine to interdisciplinary studies.

Clinical Pharmacy

Clinical Pharmacokinetics, Molecular Biopharmaceutics, Pharmacometrics, Drug Informatics

The effects and adverse reactions of medicines vary among individuals. As one of the causes of these interindividual differences, I have been focusing upon the difference in pharmacokinetics and investigated the mechanisms to create drug information useful for optimizing pharmacotherapy.

Collaborative Research Resources (Laboratory of Cell and Tissue Biology)

Anatomy, Bone cell biology

Elucidating the development and homeostasis of the skeleton through cell-cell interaction.